Fexofenadine hydrochloride inhibits histamine induced skin wheal and flare responses. It does not cross the blood-brain barrier in the rat. In laboratory animals, there is no evidence of local anesthetic, analgesic, anticonvulsant, antidepressant, antidopaminergic, antiserotonergic, anticholinergic, sedative, H2-receptor antagonist, α1-adrenergic receptor or β-adrenergic receptor blocking activity Fexofenadine HCI inhibits antigen-induced bronchospasm in sensitized guinea pigs and histamine release from peritoneal mast cells of the rat. Both enantiomers of fexofenadine display approximately equipotent antihistaminic effects.
Fexofenadine, the predominant human and animal active metabolite of terfenadine, is a selective histamine H1 - receptor antagonist.
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